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ro25 6981 tocris  (Tocris)


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    Tocris ro25 6981 tocris
    Ro25 6981 Tocris, supplied by Tocris, used in various techniques. Bioz Stars score: 93/100, based on 50 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/ro25+6981+tocris/TCN+201/pm40393456-317-262-263
    Average 93 stars, based on 50 article reviews
    ro25 6981 tocris - by Bioz Stars, 2026-11
    93/100 stars

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    Related Articles

    Ubiquitin Proteomics:

    Article Title: Arrestin-biased allosteric modulator of neurotensin receptor 1 alleviates acute and chronic pain.
    Article Snippet: Article Arrestin-biased allosteric modulator of neurotensin receptor 1 alleviates acute and chronic pain Graphical abstract Highlights • SBI-810 is a β-arrestin-2-biased allosteric modulator of neurotensin receptor 1 • Systemic or local SBI-810 injection inhibits acute and chronic pain in rodent models • SBI-810 blocks peripheral and central sensitization in DRG and spinal cord neurons • SBI-810 mitigates opioid abuse and does not impair motor and cognitive function Authors Ran Guo, Ouyang Chen, Yang Zhou, ..., William C. Wetsel, Lawrence S. Barak, Ru-Rong Ji Correspondence ru-rong.ji@duke.edu In brief SBI-810, an arrestin-biased allosteric modulator of neurotensin receptor 1, can effectively alleviate acute and chronic pain in rodent models via peripheral and central modulation and can also mitigate opioid withdrawal effects.. Guo et al., 2025, Cell 188, 4332–4349 August 7, 2025 © 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies. https://doi.org/10.1016/j.cell.2025.04.038 ll

    Virus:

    Article Title: Arrestin-biased allosteric modulator of neurotensin receptor 1 alleviates acute and chronic pain.
    Article Snippet: Article Arrestin-biased allosteric modulator of neurotensin receptor 1 alleviates acute and chronic pain Graphical abstract Highlights • SBI-810 is a β-arrestin-2-biased allosteric modulator of neurotensin receptor 1 • Systemic or local SBI-810 injection inhibits acute and chronic pain in rodent models • SBI-810 blocks peripheral and central sensitization in DRG and spinal cord neurons • SBI-810 mitigates opioid abuse and does not impair motor and cognitive function Authors Ran Guo, Ouyang Chen, Yang Zhou, ..., William C. Wetsel, Lawrence S. Barak, Ru-Rong Ji Correspondence ru-rong.ji@duke.edu In brief SBI-810, an arrestin-biased allosteric modulator of neurotensin receptor 1, can effectively alleviate acute and chronic pain in rodent models via peripheral and central modulation and can also mitigate opioid withdrawal effects.. Guo et al., 2025, Cell 188, 4332–4349 August 7, 2025 © 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies. https://doi.org/10.1016/j.cell.2025.04.038 ll

    Recombinant:

    Article Title: Arrestin-biased allosteric modulator of neurotensin receptor 1 alleviates acute and chronic pain.
    Article Snippet: Article Arrestin-biased allosteric modulator of neurotensin receptor 1 alleviates acute and chronic pain Graphical abstract Highlights • SBI-810 is a β-arrestin-2-biased allosteric modulator of neurotensin receptor 1 • Systemic or local SBI-810 injection inhibits acute and chronic pain in rodent models • SBI-810 blocks peripheral and central sensitization in DRG and spinal cord neurons • SBI-810 mitigates opioid abuse and does not impair motor and cognitive function Authors Ran Guo, Ouyang Chen, Yang Zhou, ..., William C. Wetsel, Lawrence S. Barak, Ru-Rong Ji Correspondence ru-rong.ji@duke.edu In brief SBI-810, an arrestin-biased allosteric modulator of neurotensin receptor 1, can effectively alleviate acute and chronic pain in rodent models via peripheral and central modulation and can also mitigate opioid withdrawal effects.. Guo et al., 2025, Cell 188, 4332–4349 August 7, 2025 © 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies. https://doi.org/10.1016/j.cell.2025.04.038 ll

    Adjuvant:

    Article Title: Arrestin-biased allosteric modulator of neurotensin receptor 1 alleviates acute and chronic pain.
    Article Snippet: Article Arrestin-biased allosteric modulator of neurotensin receptor 1 alleviates acute and chronic pain Graphical abstract Highlights • SBI-810 is a β-arrestin-2-biased allosteric modulator of neurotensin receptor 1 • Systemic or local SBI-810 injection inhibits acute and chronic pain in rodent models • SBI-810 blocks peripheral and central sensitization in DRG and spinal cord neurons • SBI-810 mitigates opioid abuse and does not impair motor and cognitive function Authors Ran Guo, Ouyang Chen, Yang Zhou, ..., William C. Wetsel, Lawrence S. Barak, Ru-Rong Ji Correspondence ru-rong.ji@duke.edu In brief SBI-810, an arrestin-biased allosteric modulator of neurotensin receptor 1, can effectively alleviate acute and chronic pain in rodent models via peripheral and central modulation and can also mitigate opioid withdrawal effects.. Guo et al., 2025, Cell 188, 4332–4349 August 7, 2025 © 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies. https://doi.org/10.1016/j.cell.2025.04.038 ll

    Imaging:

    Article Title: NMDA receptor-dependent prostaglandin-endoperoxide synthase 2 induction in neurons promotes glial proliferation during brain development and injury.
    Article Snippet: REAGENT or RESOURCE SOURCE IDENTIFIER Ketamine Gutian Pharma Co. N/A L-798106 Tocris Cat#3342/10 LY341495 Tocris Cat#1209/1 MK801 Tocris Cat#0924/10 MTEP Tocris Cat#2921/10 NBQX Tocris Cat#0373/10 Neurobasal medium Thermo Fisher Cat#21103049 NVP-AAM077 Tocris Cat#5018/10 Papain Worthington Biochemical Corporation Cat#LS003120 Penicillin/Streptomycin Thermo Fisher Cat#15140163 Picrotoxin Sigma Cat#P1675 Ro25-6981 Tocris Cat#1594/1 SC51322 Tocris Cat#2791/10 SC58125 Tocris Cat#2895/10 Trizol Thermo Fisher Cat#15596018 TrkB-FC R&D systems Cat#688-TK Tetrodotoxin Sigma Cat#T8024 Critical commercial assays Click-iT EdU Alexa Fluor 488 Imaging kit Thermo Fisher Cat#C10337 Click-iT EdU Alexa Fluor 594 Imaging kit Thermo Fisher Cat#C10339 NEB Next Ultra RNA library Prep Kit New England Biolabs Cat#E7760S NEB Next Poly(A) mRNA Magnetic Isolation Module New England Biolabs Cat#E7490S QuantiTect SYBR Green RT-PCR Kit Qiagen Cat#204243 TURBO DNA-free kit Thermo Fisher Cat#AM1907 Deposited data RNA-seq dataset This paper Accession # GEO:GSE139080 Microarray dataset This paper Accession # GEO:GSE89802 Experimental models: Organisms/strains Mouse: C57BL6/J Charles River (China) 213 Mouse: GFAP-GFP Zhuo et al., 1997 JAX:003257, RRID: IMSR_JAX:003257 Mouse: Grin2a em1(flox)Smoc This paper N/A Software and algorithms Prism 6 GraphPad Software https://www.graphpad.com/ scientifificsoftware/prism/ ImageJ, version 1.52r National Institutes of Health https://imagej.nih.gov/ij/ R R: The R Project for Statistical Computing https://www.r-project.org/ GeneGo pathway analysis GeneGo platform https://www.genego.com .. REAGENT or RESOURCE SOURCE IDENTIFIER Ketamine Gutian Pharma Co. N/A L-798106 Tocris Cat#3342/10 LY341495 Tocris Cat#1209/1 MK801 Tocris Cat#0924/10 MTEP Tocris Cat#2921/10 NBQX Tocris Cat#0373/10 Neurobasal medium Thermo Fisher Cat#21103049 NVP-AAM077 Tocris Cat#5018/10 Papain Worthington Biochemical Corporation Cat#LS003120 Penicillin/Streptomycin Thermo Fisher Cat#15140163 Picrotoxin Sigma Cat#P1675 Ro25-6981 Tocris Cat#1594/1 SC51322 Tocris Cat#2791/10 SC58125 Tocris Cat#2895/10 Trizol Thermo Fisher Cat#15596018 TrkB-FC R&D systems Cat#688-TK Tetrodotoxin Sigma Cat#T8024 Critical commercial assays Click-iT EdU Alexa Fluor 488 Imaging kit Thermo Fisher Cat#C10337 Click-iT EdU Alexa Fluor 594 Imaging kit Thermo Fisher Cat#C10339 NEB Next Ultra RNA library Prep Kit New England Biolabs Cat#E7760S NEB Next Poly(A) mRNA Magnetic Isolation Module New England Biolabs Cat#E7490S QuantiTect SYBR Green RT-PCR Kit Qiagen Cat#204243 TURBO DNA-free kit Thermo Fisher Cat#AM1907 Deposited data RNA-seq dataset This paper Accession # GEO:GSE139080 Microarray dataset This paper Accession # GEO:GSE89802 Experimental models: Organisms/strains Mouse: C57BL6/J Charles River (China) 213 Mouse: GFAP-GFP Zhuo et al., 1997 JAX:003257, RRID: IMSR_JAX:003257 Mouse: Grin2a em1(flox)Smoc This paper N/A Software and algorithms Prism 6 GraphPad Software https://www.graphpad.com/ scientifificsoftware/prism/ ImageJ, version 1.52r National Institutes of Health https://imagej.nih.gov/ij/ R R: The R Project for Statistical Computing https://www.r-project.org/ GeneGo pathway analysis GeneGo platform https://www.genego.com ..

    Isolation:

    Article Title: NMDA receptor-dependent prostaglandin-endoperoxide synthase 2 induction in neurons promotes glial proliferation during brain development and injury.
    Article Snippet: REAGENT or RESOURCE SOURCE IDENTIFIER Ketamine Gutian Pharma Co. N/A L-798106 Tocris Cat#3342/10 LY341495 Tocris Cat#1209/1 MK801 Tocris Cat#0924/10 MTEP Tocris Cat#2921/10 NBQX Tocris Cat#0373/10 Neurobasal medium Thermo Fisher Cat#21103049 NVP-AAM077 Tocris Cat#5018/10 Papain Worthington Biochemical Corporation Cat#LS003120 Penicillin/Streptomycin Thermo Fisher Cat#15140163 Picrotoxin Sigma Cat#P1675 Ro25-6981 Tocris Cat#1594/1 SC51322 Tocris Cat#2791/10 SC58125 Tocris Cat#2895/10 Trizol Thermo Fisher Cat#15596018 TrkB-FC R&D systems Cat#688-TK Tetrodotoxin Sigma Cat#T8024 Critical commercial assays Click-iT EdU Alexa Fluor 488 Imaging kit Thermo Fisher Cat#C10337 Click-iT EdU Alexa Fluor 594 Imaging kit Thermo Fisher Cat#C10339 NEB Next Ultra RNA library Prep Kit New England Biolabs Cat#E7760S NEB Next Poly(A) mRNA Magnetic Isolation Module New England Biolabs Cat#E7490S QuantiTect SYBR Green RT-PCR Kit Qiagen Cat#204243 TURBO DNA-free kit Thermo Fisher Cat#AM1907 Deposited data RNA-seq dataset This paper Accession # GEO:GSE139080 Microarray dataset This paper Accession # GEO:GSE89802 Experimental models: Organisms/strains Mouse: C57BL6/J Charles River (China) 213 Mouse: GFAP-GFP Zhuo et al., 1997 JAX:003257, RRID: IMSR_JAX:003257 Mouse: Grin2a em1(flox)Smoc This paper N/A Software and algorithms Prism 6 GraphPad Software https://www.graphpad.com/ scientifificsoftware/prism/ ImageJ, version 1.52r National Institutes of Health https://imagej.nih.gov/ij/ R R: The R Project for Statistical Computing https://www.r-project.org/ GeneGo pathway analysis GeneGo platform https://www.genego.com .. REAGENT or RESOURCE SOURCE IDENTIFIER Ketamine Gutian Pharma Co. N/A L-798106 Tocris Cat#3342/10 LY341495 Tocris Cat#1209/1 MK801 Tocris Cat#0924/10 MTEP Tocris Cat#2921/10 NBQX Tocris Cat#0373/10 Neurobasal medium Thermo Fisher Cat#21103049 NVP-AAM077 Tocris Cat#5018/10 Papain Worthington Biochemical Corporation Cat#LS003120 Penicillin/Streptomycin Thermo Fisher Cat#15140163 Picrotoxin Sigma Cat#P1675 Ro25-6981 Tocris Cat#1594/1 SC51322 Tocris Cat#2791/10 SC58125 Tocris Cat#2895/10 Trizol Thermo Fisher Cat#15596018 TrkB-FC R&D systems Cat#688-TK Tetrodotoxin Sigma Cat#T8024 Critical commercial assays Click-iT EdU Alexa Fluor 488 Imaging kit Thermo Fisher Cat#C10337 Click-iT EdU Alexa Fluor 594 Imaging kit Thermo Fisher Cat#C10339 NEB Next Ultra RNA library Prep Kit New England Biolabs Cat#E7760S NEB Next Poly(A) mRNA Magnetic Isolation Module New England Biolabs Cat#E7490S QuantiTect SYBR Green RT-PCR Kit Qiagen Cat#204243 TURBO DNA-free kit Thermo Fisher Cat#AM1907 Deposited data RNA-seq dataset This paper Accession # GEO:GSE139080 Microarray dataset This paper Accession # GEO:GSE89802 Experimental models: Organisms/strains Mouse: C57BL6/J Charles River (China) 213 Mouse: GFAP-GFP Zhuo et al., 1997 JAX:003257, RRID: IMSR_JAX:003257 Mouse: Grin2a em1(flox)Smoc This paper N/A Software and algorithms Prism 6 GraphPad Software https://www.graphpad.com/ scientifificsoftware/prism/ ImageJ, version 1.52r National Institutes of Health https://imagej.nih.gov/ij/ R R: The R Project for Statistical Computing https://www.r-project.org/ GeneGo pathway analysis GeneGo platform https://www.genego.com ..

    SYBR Green Assay:

    Article Title: NMDA receptor-dependent prostaglandin-endoperoxide synthase 2 induction in neurons promotes glial proliferation during brain development and injury.
    Article Snippet: REAGENT or RESOURCE SOURCE IDENTIFIER Ketamine Gutian Pharma Co. N/A L-798106 Tocris Cat#3342/10 LY341495 Tocris Cat#1209/1 MK801 Tocris Cat#0924/10 MTEP Tocris Cat#2921/10 NBQX Tocris Cat#0373/10 Neurobasal medium Thermo Fisher Cat#21103049 NVP-AAM077 Tocris Cat#5018/10 Papain Worthington Biochemical Corporation Cat#LS003120 Penicillin/Streptomycin Thermo Fisher Cat#15140163 Picrotoxin Sigma Cat#P1675 Ro25-6981 Tocris Cat#1594/1 SC51322 Tocris Cat#2791/10 SC58125 Tocris Cat#2895/10 Trizol Thermo Fisher Cat#15596018 TrkB-FC R&D systems Cat#688-TK Tetrodotoxin Sigma Cat#T8024 Critical commercial assays Click-iT EdU Alexa Fluor 488 Imaging kit Thermo Fisher Cat#C10337 Click-iT EdU Alexa Fluor 594 Imaging kit Thermo Fisher Cat#C10339 NEB Next Ultra RNA library Prep Kit New England Biolabs Cat#E7760S NEB Next Poly(A) mRNA Magnetic Isolation Module New England Biolabs Cat#E7490S QuantiTect SYBR Green RT-PCR Kit Qiagen Cat#204243 TURBO DNA-free kit Thermo Fisher Cat#AM1907 Deposited data RNA-seq dataset This paper Accession # GEO:GSE139080 Microarray dataset This paper Accession # GEO:GSE89802 Experimental models: Organisms/strains Mouse: C57BL6/J Charles River (China) 213 Mouse: GFAP-GFP Zhuo et al., 1997 JAX:003257, RRID: IMSR_JAX:003257 Mouse: Grin2a em1(flox)Smoc This paper N/A Software and algorithms Prism 6 GraphPad Software https://www.graphpad.com/ scientifificsoftware/prism/ ImageJ, version 1.52r National Institutes of Health https://imagej.nih.gov/ij/ R R: The R Project for Statistical Computing https://www.r-project.org/ GeneGo pathway analysis GeneGo platform https://www.genego.com .. REAGENT or RESOURCE SOURCE IDENTIFIER Ketamine Gutian Pharma Co. N/A L-798106 Tocris Cat#3342/10 LY341495 Tocris Cat#1209/1 MK801 Tocris Cat#0924/10 MTEP Tocris Cat#2921/10 NBQX Tocris Cat#0373/10 Neurobasal medium Thermo Fisher Cat#21103049 NVP-AAM077 Tocris Cat#5018/10 Papain Worthington Biochemical Corporation Cat#LS003120 Penicillin/Streptomycin Thermo Fisher Cat#15140163 Picrotoxin Sigma Cat#P1675 Ro25-6981 Tocris Cat#1594/1 SC51322 Tocris Cat#2791/10 SC58125 Tocris Cat#2895/10 Trizol Thermo Fisher Cat#15596018 TrkB-FC R&D systems Cat#688-TK Tetrodotoxin Sigma Cat#T8024 Critical commercial assays Click-iT EdU Alexa Fluor 488 Imaging kit Thermo Fisher Cat#C10337 Click-iT EdU Alexa Fluor 594 Imaging kit Thermo Fisher Cat#C10339 NEB Next Ultra RNA library Prep Kit New England Biolabs Cat#E7760S NEB Next Poly(A) mRNA Magnetic Isolation Module New England Biolabs Cat#E7490S QuantiTect SYBR Green RT-PCR Kit Qiagen Cat#204243 TURBO DNA-free kit Thermo Fisher Cat#AM1907 Deposited data RNA-seq dataset This paper Accession # GEO:GSE139080 Microarray dataset This paper Accession # GEO:GSE89802 Experimental models: Organisms/strains Mouse: C57BL6/J Charles River (China) 213 Mouse: GFAP-GFP Zhuo et al., 1997 JAX:003257, RRID: IMSR_JAX:003257 Mouse: Grin2a em1(flox)Smoc This paper N/A Software and algorithms Prism 6 GraphPad Software https://www.graphpad.com/ scientifificsoftware/prism/ ImageJ, version 1.52r National Institutes of Health https://imagej.nih.gov/ij/ R R: The R Project for Statistical Computing https://www.r-project.org/ GeneGo pathway analysis GeneGo platform https://www.genego.com ..

    Reverse Transcription Polymerase Chain Reaction:

    Article Title: NMDA receptor-dependent prostaglandin-endoperoxide synthase 2 induction in neurons promotes glial proliferation during brain development and injury.
    Article Snippet: REAGENT or RESOURCE SOURCE IDENTIFIER Ketamine Gutian Pharma Co. N/A L-798106 Tocris Cat#3342/10 LY341495 Tocris Cat#1209/1 MK801 Tocris Cat#0924/10 MTEP Tocris Cat#2921/10 NBQX Tocris Cat#0373/10 Neurobasal medium Thermo Fisher Cat#21103049 NVP-AAM077 Tocris Cat#5018/10 Papain Worthington Biochemical Corporation Cat#LS003120 Penicillin/Streptomycin Thermo Fisher Cat#15140163 Picrotoxin Sigma Cat#P1675 Ro25-6981 Tocris Cat#1594/1 SC51322 Tocris Cat#2791/10 SC58125 Tocris Cat#2895/10 Trizol Thermo Fisher Cat#15596018 TrkB-FC R&D systems Cat#688-TK Tetrodotoxin Sigma Cat#T8024 Critical commercial assays Click-iT EdU Alexa Fluor 488 Imaging kit Thermo Fisher Cat#C10337 Click-iT EdU Alexa Fluor 594 Imaging kit Thermo Fisher Cat#C10339 NEB Next Ultra RNA library Prep Kit New England Biolabs Cat#E7760S NEB Next Poly(A) mRNA Magnetic Isolation Module New England Biolabs Cat#E7490S QuantiTect SYBR Green RT-PCR Kit Qiagen Cat#204243 TURBO DNA-free kit Thermo Fisher Cat#AM1907 Deposited data RNA-seq dataset This paper Accession # GEO:GSE139080 Microarray dataset This paper Accession # GEO:GSE89802 Experimental models: Organisms/strains Mouse: C57BL6/J Charles River (China) 213 Mouse: GFAP-GFP Zhuo et al., 1997 JAX:003257, RRID: IMSR_JAX:003257 Mouse: Grin2a em1(flox)Smoc This paper N/A Software and algorithms Prism 6 GraphPad Software https://www.graphpad.com/ scientifificsoftware/prism/ ImageJ, version 1.52r National Institutes of Health https://imagej.nih.gov/ij/ R R: The R Project for Statistical Computing https://www.r-project.org/ GeneGo pathway analysis GeneGo platform https://www.genego.com .. REAGENT or RESOURCE SOURCE IDENTIFIER Ketamine Gutian Pharma Co. N/A L-798106 Tocris Cat#3342/10 LY341495 Tocris Cat#1209/1 MK801 Tocris Cat#0924/10 MTEP Tocris Cat#2921/10 NBQX Tocris Cat#0373/10 Neurobasal medium Thermo Fisher Cat#21103049 NVP-AAM077 Tocris Cat#5018/10 Papain Worthington Biochemical Corporation Cat#LS003120 Penicillin/Streptomycin Thermo Fisher Cat#15140163 Picrotoxin Sigma Cat#P1675 Ro25-6981 Tocris Cat#1594/1 SC51322 Tocris Cat#2791/10 SC58125 Tocris Cat#2895/10 Trizol Thermo Fisher Cat#15596018 TrkB-FC R&D systems Cat#688-TK Tetrodotoxin Sigma Cat#T8024 Critical commercial assays Click-iT EdU Alexa Fluor 488 Imaging kit Thermo Fisher Cat#C10337 Click-iT EdU Alexa Fluor 594 Imaging kit Thermo Fisher Cat#C10339 NEB Next Ultra RNA library Prep Kit New England Biolabs Cat#E7760S NEB Next Poly(A) mRNA Magnetic Isolation Module New England Biolabs Cat#E7490S QuantiTect SYBR Green RT-PCR Kit Qiagen Cat#204243 TURBO DNA-free kit Thermo Fisher Cat#AM1907 Deposited data RNA-seq dataset This paper Accession # GEO:GSE139080 Microarray dataset This paper Accession # GEO:GSE89802 Experimental models: Organisms/strains Mouse: C57BL6/J Charles River (China) 213 Mouse: GFAP-GFP Zhuo et al., 1997 JAX:003257, RRID: IMSR_JAX:003257 Mouse: Grin2a em1(flox)Smoc This paper N/A Software and algorithms Prism 6 GraphPad Software https://www.graphpad.com/ scientifificsoftware/prism/ ImageJ, version 1.52r National Institutes of Health https://imagej.nih.gov/ij/ R R: The R Project for Statistical Computing https://www.r-project.org/ GeneGo pathway analysis GeneGo platform https://www.genego.com ..

    RNA Sequencing:

    Article Title: NMDA receptor-dependent prostaglandin-endoperoxide synthase 2 induction in neurons promotes glial proliferation during brain development and injury.
    Article Snippet: REAGENT or RESOURCE SOURCE IDENTIFIER Ketamine Gutian Pharma Co. N/A L-798106 Tocris Cat#3342/10 LY341495 Tocris Cat#1209/1 MK801 Tocris Cat#0924/10 MTEP Tocris Cat#2921/10 NBQX Tocris Cat#0373/10 Neurobasal medium Thermo Fisher Cat#21103049 NVP-AAM077 Tocris Cat#5018/10 Papain Worthington Biochemical Corporation Cat#LS003120 Penicillin/Streptomycin Thermo Fisher Cat#15140163 Picrotoxin Sigma Cat#P1675 Ro25-6981 Tocris Cat#1594/1 SC51322 Tocris Cat#2791/10 SC58125 Tocris Cat#2895/10 Trizol Thermo Fisher Cat#15596018 TrkB-FC R&D systems Cat#688-TK Tetrodotoxin Sigma Cat#T8024 Critical commercial assays Click-iT EdU Alexa Fluor 488 Imaging kit Thermo Fisher Cat#C10337 Click-iT EdU Alexa Fluor 594 Imaging kit Thermo Fisher Cat#C10339 NEB Next Ultra RNA library Prep Kit New England Biolabs Cat#E7760S NEB Next Poly(A) mRNA Magnetic Isolation Module New England Biolabs Cat#E7490S QuantiTect SYBR Green RT-PCR Kit Qiagen Cat#204243 TURBO DNA-free kit Thermo Fisher Cat#AM1907 Deposited data RNA-seq dataset This paper Accession # GEO:GSE139080 Microarray dataset This paper Accession # GEO:GSE89802 Experimental models: Organisms/strains Mouse: C57BL6/J Charles River (China) 213 Mouse: GFAP-GFP Zhuo et al., 1997 JAX:003257, RRID: IMSR_JAX:003257 Mouse: Grin2a em1(flox)Smoc This paper N/A Software and algorithms Prism 6 GraphPad Software https://www.graphpad.com/ scientifificsoftware/prism/ ImageJ, version 1.52r National Institutes of Health https://imagej.nih.gov/ij/ R R: The R Project for Statistical Computing https://www.r-project.org/ GeneGo pathway analysis GeneGo platform https://www.genego.com .. REAGENT or RESOURCE SOURCE IDENTIFIER Ketamine Gutian Pharma Co. N/A L-798106 Tocris Cat#3342/10 LY341495 Tocris Cat#1209/1 MK801 Tocris Cat#0924/10 MTEP Tocris Cat#2921/10 NBQX Tocris Cat#0373/10 Neurobasal medium Thermo Fisher Cat#21103049 NVP-AAM077 Tocris Cat#5018/10 Papain Worthington Biochemical Corporation Cat#LS003120 Penicillin/Streptomycin Thermo Fisher Cat#15140163 Picrotoxin Sigma Cat#P1675 Ro25-6981 Tocris Cat#1594/1 SC51322 Tocris Cat#2791/10 SC58125 Tocris Cat#2895/10 Trizol Thermo Fisher Cat#15596018 TrkB-FC R&D systems Cat#688-TK Tetrodotoxin Sigma Cat#T8024 Critical commercial assays Click-iT EdU Alexa Fluor 488 Imaging kit Thermo Fisher Cat#C10337 Click-iT EdU Alexa Fluor 594 Imaging kit Thermo Fisher Cat#C10339 NEB Next Ultra RNA library Prep Kit New England Biolabs Cat#E7760S NEB Next Poly(A) mRNA Magnetic Isolation Module New England Biolabs Cat#E7490S QuantiTect SYBR Green RT-PCR Kit Qiagen Cat#204243 TURBO DNA-free kit Thermo Fisher Cat#AM1907 Deposited data RNA-seq dataset This paper Accession # GEO:GSE139080 Microarray dataset This paper Accession # GEO:GSE89802 Experimental models: Organisms/strains Mouse: C57BL6/J Charles River (China) 213 Mouse: GFAP-GFP Zhuo et al., 1997 JAX:003257, RRID: IMSR_JAX:003257 Mouse: Grin2a em1(flox)Smoc This paper N/A Software and algorithms Prism 6 GraphPad Software https://www.graphpad.com/ scientifificsoftware/prism/ ImageJ, version 1.52r National Institutes of Health https://imagej.nih.gov/ij/ R R: The R Project for Statistical Computing https://www.r-project.org/ GeneGo pathway analysis GeneGo platform https://www.genego.com ..

    Microarray:

    Article Title: NMDA receptor-dependent prostaglandin-endoperoxide synthase 2 induction in neurons promotes glial proliferation during brain development and injury.
    Article Snippet: REAGENT or RESOURCE SOURCE IDENTIFIER Ketamine Gutian Pharma Co. N/A L-798106 Tocris Cat#3342/10 LY341495 Tocris Cat#1209/1 MK801 Tocris Cat#0924/10 MTEP Tocris Cat#2921/10 NBQX Tocris Cat#0373/10 Neurobasal medium Thermo Fisher Cat#21103049 NVP-AAM077 Tocris Cat#5018/10 Papain Worthington Biochemical Corporation Cat#LS003120 Penicillin/Streptomycin Thermo Fisher Cat#15140163 Picrotoxin Sigma Cat#P1675 Ro25-6981 Tocris Cat#1594/1 SC51322 Tocris Cat#2791/10 SC58125 Tocris Cat#2895/10 Trizol Thermo Fisher Cat#15596018 TrkB-FC R&D systems Cat#688-TK Tetrodotoxin Sigma Cat#T8024 Critical commercial assays Click-iT EdU Alexa Fluor 488 Imaging kit Thermo Fisher Cat#C10337 Click-iT EdU Alexa Fluor 594 Imaging kit Thermo Fisher Cat#C10339 NEB Next Ultra RNA library Prep Kit New England Biolabs Cat#E7760S NEB Next Poly(A) mRNA Magnetic Isolation Module New England Biolabs Cat#E7490S QuantiTect SYBR Green RT-PCR Kit Qiagen Cat#204243 TURBO DNA-free kit Thermo Fisher Cat#AM1907 Deposited data RNA-seq dataset This paper Accession # GEO:GSE139080 Microarray dataset This paper Accession # GEO:GSE89802 Experimental models: Organisms/strains Mouse: C57BL6/J Charles River (China) 213 Mouse: GFAP-GFP Zhuo et al., 1997 JAX:003257, RRID: IMSR_JAX:003257 Mouse: Grin2a em1(flox)Smoc This paper N/A Software and algorithms Prism 6 GraphPad Software https://www.graphpad.com/ scientifificsoftware/prism/ ImageJ, version 1.52r National Institutes of Health https://imagej.nih.gov/ij/ R R: The R Project for Statistical Computing https://www.r-project.org/ GeneGo pathway analysis GeneGo platform https://www.genego.com .. REAGENT or RESOURCE SOURCE IDENTIFIER Ketamine Gutian Pharma Co. N/A L-798106 Tocris Cat#3342/10 LY341495 Tocris Cat#1209/1 MK801 Tocris Cat#0924/10 MTEP Tocris Cat#2921/10 NBQX Tocris Cat#0373/10 Neurobasal medium Thermo Fisher Cat#21103049 NVP-AAM077 Tocris Cat#5018/10 Papain Worthington Biochemical Corporation Cat#LS003120 Penicillin/Streptomycin Thermo Fisher Cat#15140163 Picrotoxin Sigma Cat#P1675 Ro25-6981 Tocris Cat#1594/1 SC51322 Tocris Cat#2791/10 SC58125 Tocris Cat#2895/10 Trizol Thermo Fisher Cat#15596018 TrkB-FC R&D systems Cat#688-TK Tetrodotoxin Sigma Cat#T8024 Critical commercial assays Click-iT EdU Alexa Fluor 488 Imaging kit Thermo Fisher Cat#C10337 Click-iT EdU Alexa Fluor 594 Imaging kit Thermo Fisher Cat#C10339 NEB Next Ultra RNA library Prep Kit New England Biolabs Cat#E7760S NEB Next Poly(A) mRNA Magnetic Isolation Module New England Biolabs Cat#E7490S QuantiTect SYBR Green RT-PCR Kit Qiagen Cat#204243 TURBO DNA-free kit Thermo Fisher Cat#AM1907 Deposited data RNA-seq dataset This paper Accession # GEO:GSE139080 Microarray dataset This paper Accession # GEO:GSE89802 Experimental models: Organisms/strains Mouse: C57BL6/J Charles River (China) 213 Mouse: GFAP-GFP Zhuo et al., 1997 JAX:003257, RRID: IMSR_JAX:003257 Mouse: Grin2a em1(flox)Smoc This paper N/A Software and algorithms Prism 6 GraphPad Software https://www.graphpad.com/ scientifificsoftware/prism/ ImageJ, version 1.52r National Institutes of Health https://imagej.nih.gov/ij/ R R: The R Project for Statistical Computing https://www.r-project.org/ GeneGo pathway analysis GeneGo platform https://www.genego.com ..

    Software:

    Article Title: NMDA receptor-dependent prostaglandin-endoperoxide synthase 2 induction in neurons promotes glial proliferation during brain development and injury.
    Article Snippet: REAGENT or RESOURCE SOURCE IDENTIFIER Ketamine Gutian Pharma Co. N/A L-798106 Tocris Cat#3342/10 LY341495 Tocris Cat#1209/1 MK801 Tocris Cat#0924/10 MTEP Tocris Cat#2921/10 NBQX Tocris Cat#0373/10 Neurobasal medium Thermo Fisher Cat#21103049 NVP-AAM077 Tocris Cat#5018/10 Papain Worthington Biochemical Corporation Cat#LS003120 Penicillin/Streptomycin Thermo Fisher Cat#15140163 Picrotoxin Sigma Cat#P1675 Ro25-6981 Tocris Cat#1594/1 SC51322 Tocris Cat#2791/10 SC58125 Tocris Cat#2895/10 Trizol Thermo Fisher Cat#15596018 TrkB-FC R&D systems Cat#688-TK Tetrodotoxin Sigma Cat#T8024 Critical commercial assays Click-iT EdU Alexa Fluor 488 Imaging kit Thermo Fisher Cat#C10337 Click-iT EdU Alexa Fluor 594 Imaging kit Thermo Fisher Cat#C10339 NEB Next Ultra RNA library Prep Kit New England Biolabs Cat#E7760S NEB Next Poly(A) mRNA Magnetic Isolation Module New England Biolabs Cat#E7490S QuantiTect SYBR Green RT-PCR Kit Qiagen Cat#204243 TURBO DNA-free kit Thermo Fisher Cat#AM1907 Deposited data RNA-seq dataset This paper Accession # GEO:GSE139080 Microarray dataset This paper Accession # GEO:GSE89802 Experimental models: Organisms/strains Mouse: C57BL6/J Charles River (China) 213 Mouse: GFAP-GFP Zhuo et al., 1997 JAX:003257, RRID: IMSR_JAX:003257 Mouse: Grin2a em1(flox)Smoc This paper N/A Software and algorithms Prism 6 GraphPad Software https://www.graphpad.com/ scientifificsoftware/prism/ ImageJ, version 1.52r National Institutes of Health https://imagej.nih.gov/ij/ R R: The R Project for Statistical Computing https://www.r-project.org/ GeneGo pathway analysis GeneGo platform https://www.genego.com .. REAGENT or RESOURCE SOURCE IDENTIFIER Ketamine Gutian Pharma Co. N/A L-798106 Tocris Cat#3342/10 LY341495 Tocris Cat#1209/1 MK801 Tocris Cat#0924/10 MTEP Tocris Cat#2921/10 NBQX Tocris Cat#0373/10 Neurobasal medium Thermo Fisher Cat#21103049 NVP-AAM077 Tocris Cat#5018/10 Papain Worthington Biochemical Corporation Cat#LS003120 Penicillin/Streptomycin Thermo Fisher Cat#15140163 Picrotoxin Sigma Cat#P1675 Ro25-6981 Tocris Cat#1594/1 SC51322 Tocris Cat#2791/10 SC58125 Tocris Cat#2895/10 Trizol Thermo Fisher Cat#15596018 TrkB-FC R&D systems Cat#688-TK Tetrodotoxin Sigma Cat#T8024 Critical commercial assays Click-iT EdU Alexa Fluor 488 Imaging kit Thermo Fisher Cat#C10337 Click-iT EdU Alexa Fluor 594 Imaging kit Thermo Fisher Cat#C10339 NEB Next Ultra RNA library Prep Kit New England Biolabs Cat#E7760S NEB Next Poly(A) mRNA Magnetic Isolation Module New England Biolabs Cat#E7490S QuantiTect SYBR Green RT-PCR Kit Qiagen Cat#204243 TURBO DNA-free kit Thermo Fisher Cat#AM1907 Deposited data RNA-seq dataset This paper Accession # GEO:GSE139080 Microarray dataset This paper Accession # GEO:GSE89802 Experimental models: Organisms/strains Mouse: C57BL6/J Charles River (China) 213 Mouse: GFAP-GFP Zhuo et al., 1997 JAX:003257, RRID: IMSR_JAX:003257 Mouse: Grin2a em1(flox)Smoc This paper N/A Software and algorithms Prism 6 GraphPad Software https://www.graphpad.com/ scientifificsoftware/prism/ ImageJ, version 1.52r National Institutes of Health https://imagej.nih.gov/ij/ R R: The R Project for Statistical Computing https://www.r-project.org/ GeneGo pathway analysis GeneGo platform https://www.genego.com ..



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